The incident occurred in the parking lot near the VHS vocational building.
Chief Deputy Tony Allen said the circumstances of the accident are under investigation and no details could be released Monday.
Allen noted, however that neither student suffered life-threatening injuries, although one boy was seriously injured, and both were transported to Holston Valley Medical Center by Hawkins County EMS.
A source within the school told the Times News some boys were moving trash in a pickup when they were thrown out of the back of the truck.
One student suffered a serious laceration to his stomach, and the other suffered a seizure, according to the school source.
With regards to riding in the back of a pickup, the Tennessee Rules of the Road are different depending on the type of road you are on.
On a municipal street or county road, anyone 6 and older is free to ride in the bed of the truck.
On a state highway or interstate, you must be at least 12 years old to ride in the bed of the truck.